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10.1016/s0092-8674(00)81871-1 56 LiM.BrooksC

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More direct evidence for the translocation of zinc was provided by the findings of Koh and others (11), who demonstrated that during a brief period of global ischemia, intracellular zinc accumulation in vulnerable CA1 pyramidal hippocampal neurons preceded degeneration, which could be prevented with the intracerebroventricular administration of the high affinity, membrane-impermeable zinc-chelator, ethylenediaminetetraacetic acid (EDTA) saturated with calcium (Ca-EDTA)

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