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NNMT has become a significant focus in metabolic research due to its association with obesity, insulin resistance, aging, and altered mitochondrial function

The most common adverse reactions are related to gastrointestinal adjustments and administration site responses with subcutaneous injection protocols

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Human studies using Lactobacillus as a probiotic have often demonstrated decreased body weight and/or body fat in a strain-dependent manner (for a review of human studies, see Crovesy et al., 2017 58 ), suggesting that the NNMTi-and-LD-mediated changes to Lactobacillus relative abundance may be critical to NNMTi-mediated weight loss