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Thus, how nicotine affects cell signaling and gene expression programs in breast cancer cells is a critical unresolved question that may help explain differences in outcome due to lifetime tobacco-use

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Few studies incorporate objective clinical measures of lung function or fitness, leading to concerns about inconsistent or non-standardized assessment across studies

As smoking rates have fallen, the use of vapes has risen, with about 5.1 million people using a vape or e-cigarette in 2023