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Additionally, A has been observed to localize to mitochondria and to produce free radicals impairing the bioenergetic machinery (Manczak et al., 2004

This dimeric form of Prx2 is non-functional, but the disulfide bridge between the subunits can be broken by Trx, regenerating Prx2, and completing the catalytic cycle [73]

Lifelong PE was diagnosed by an experienced andrologist on the basis of the International Society of Sexual Medicine (ISSM) definitions 3 , including the evaluation of intravaginal ejaculatory latency time (IELT) by stopwatch 18

Preclinical studies have described the role of Vitamin E in AD: it seems to reduce transepidermal water loss (TEWL), which is associated with AD pathogenesis, and to induce the expression of the transglutaminase-1 gene, involved in terminal differentiation of keratinocytes and in the formation of the stratum corneum (8385)

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