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The protein tyrosine phosphatase MEG2 regulates the transport and signal transduction of tropomyosin receptor kinase A

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In an embryo-fetal development study with nirmatrelvir, reduced fetal body weights following oral administration of nirmatrelvir to pregnant rabbits were observed at systemic exposures (AUC) approximately 11 times higher than clinical exposure at the approved human dose of PAXLOVID

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