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As early as the 1970s, Tobacco Mosaic Virus (TMV) was shown to possess substantial interferon-inducing and antiviral activity in mammalian systems, comparable to synthetic interferon inducers, despite its inability to replicate in vertebrate cells ( Consistent with this framework, prophylactic induction of interferon responses can reduce susceptibility to SARS-CoV-2

Interestingly, only 68 metabolites were differentially accumulated between L and SPL samples irrespective of the cultivar or geographic location

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This push-pull dynamic creates a vicious cycle that can be tough to break