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Use of the arginine-depleting agent pegylated arginine deiminase ADI-PEG20 in GBM can increase nitric oxide (NO) synthesis and produce cytotoxic pernitrite, increasing the sensitivity of tumor cells to ionizing radiation and significantly enhancing the effect of radiotherapy on GBM

Jones PM, Burrin JM, Ghatei MA, OHalloran DJ, Legon S, Bloom SR

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The peptide stimulates the synthesis of collagen types I, III, and V, as well as glycosaminoglycans, decorin, and other extracellular matrix components essential for tissue structure

The following abbreviations are used: s, singlet