doi: 10.1002/adma.202305830 Summary Keywords bilirubin, tumor, metabolism, oxidation, inflammation, signal transduction, nanomedicine Citation Yi F, Tao S and Wu H (2025) Bilirubin metabolism in relation to cancer
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Zinc signaling is essential for NETosis, as zinc chelation by TPEN inhibits this process without affecting PKC activity or ROS production, suggesting zinc acts downstream of ROS [161]
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This supports the fact that higher enzyme expression level may lead to higher LC 50 values
It also helps protect cells from oxidative stress a natural process that may increase with physical exertion, stress or environmental influences