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BhattaraiYWilliamsBBBattaglioliEJWhitakerWRTillLGroverMet alGut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion
Interspecies scaling (for example, body-surface-area conversion) typically reduces a rodent mg/kg figure severalfold, and even a properly scaled number would still be a hypothetical exposure , not a validated dose
According to meta-analysis data, hypothyroidism occurs in about 3.8% of patients treated with anti-CTLA-4, 3.9% with anti-PD-L1, 7.0% with anti-PD-1, and 13.2% with combination therapy