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The latter oxidation reactions are essentially irreversible and hence lead to protein inactivation

DOI: 10.1111/j.1442-200x.2005.01998.x [ Links ] Clark MA, Stein REK, Silver EJ, Khalid S, Fuloria M, Esteban-Cruciani NV

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Under moderate oxidative stress, Keap1 is inhibited, allowing Nrf2 to be translocated to the nucleus, where it acts as an antioxidant

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Schwingshackl L, Boeing H, Stelmach-Mardas M, Gottschald M, Dietrich S, Arregui M, et al