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Materials and methods The study was registered at ClinicalTrials.gov (id: NCT01312571), and approval was obtained from the regional ethics committee at Ume University, Sweden (dnr: 2015-310-31 M)

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Synapse is an oral cognitive optimization protocol built around Dihexa, a synthetic peptide derived from angiotensin IV that crosses the blood-brain barrier to promote the formation of new synaptic connections