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These events are uncommon but plausible

The prevalance of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Downs syndrome and Alzheimers disease

These histological alternations are the result of cell death or degeneration and compensatory reactions within the diverse cell types comprising the kidney

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There have been several documented cases of patients with Parkinson's disease in the absence of Lewy pathology, who have parkin-related disease and in some cases a mutation in the LRRK2 gene