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The transport of inorganic Se into the brain appears to be mainly responsible for Se neurotoxicity (Vinceti et al., 2014, 2016), implementing the U-shaped effects of Se on human health (Rayman et al., 2018

We conducted an in vitro methylation assay utilizing recombinant human GST-PRMT1 protein and His-UBE2m protein to ascertain if PRMT1 could directly methylate UBE2m