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TAAR1 & Activation of NET/DAT/SERT Reverse Transport: Nature's Homeostatic Safety Valve Under baseline physiological conditions, catecholamines (like dopamine and norepinephrine) are kept sequestered at extremely low levels in the presynaptic cytoplasm (representing only ~3% of the total terminal contents), with the vast majority safely packaged in acidic storage vesicles (Hussain et al., 2023)

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Whilst it is generally safe when approached sensibly, some people do experience changes in bowel habits during the process, including looser stools or more frequent trips to the toilet

We also need to further understand if this preclinical stage is a valid representation of people who may go on to develop dementia due to Alzheimer's disease

Combined with gut-healing protocols , this approach addresses histamine intolerance from both the production and clearance sides