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Selenium metabolism and OA Physiological significance of oxidative stress in chondrocytes OA is the most common form of arthritis and is primarily characterized by the loss of cartilage-specific ECM and other pathological changes in joints including subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31

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Activated caspase-1 cleaves proIL-1 and proIL-18 into their mature, bioactive forms, which are secreted to promote local inflammation [29]

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Many researchers have focused on understanding the mode of action of inhibitors that can act differently depending on the DGF-in or DFG-out conformation