Abbreviations CaOx: Calcium oxalate EZH2: Enhancer of zeste homolog 2 PRC2: Polycomb repressive complex 2 H3K27me3: Trimethylation of histone H3 lysine 27 SLC7A11: Solute carrier family 7, member 11 SLC3A2: Solute carrier family 3, member 2 GPX4: Glutathione peroxidase 4 ACSL4: Acyl-CoA synthetase long-chain family4 PTGS2: Prostaglandin-endoperoxide synthase 2 AKI: Acute kidney injury CKD: Chronic kidney disease TEC: Tubular epithelial cell RCD: Regulated cell death ROS: Reactive oxygen species GSH: Glutathione MDA: Malondialdehyde BUN: Blood urea nitrogen Cr: Creatinine IHC: Immunohistochemistry TEM: Transmission electron microscopy CHIP: Chromatin immunoprecipitation Gly: Glyoxylic CD31: Platelet endothelial cell adhesion molecule-1 SMA: Alpha smooth muscle Actin E-cad: E-cadherin References Zeng G, et al
Furthermore, given that we have demonstrated that this mitochondrial adaptation is to promote rebalancing of pyrimidine levels, mitochondrial biogenesis could also be used to identify patient cohorts likely to benefit from UCK2 inhibitor combinations
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