107(6):771781 Endocrine and metabolic roles of insulin-like growth factor signaling in experimental models Sjgren K, Jansson JO, Isaksson OG, Ohlsson C., Minerva Endocrinologica , 2002
Petrow, R
117 Probably due to the hepatotoxic effects of Statins, doctors may not prescribe statins to patients with high plasma aminotransferase levels
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IV infusions bypass that issue but require time, cost, and access to a clinic
HGHs anabolic effects are mediated primarily through IGF-1, which then acts on peripheral tissues such as muscle and bone. Laron, Z., Pediatric Endocrinology Reviews IGF-1 LR3: Direct Muscle Growth Stimulator IGF-1 LR3 binds directly to IGF-1 receptors on muscle fibers, triggering: Muscle cell differentiation and proliferation Activation of satellite cells , essential for muscle repair and new muscle fiber growth Enhanced nutrient uptake (glucose, amino acids, creatine) Because of this direct action , IGF-1 LR3 can stimulate local muscle hypertrophy without relying on systemic conversion pathways
