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Husbandry factors and experimental design A randomised block design of a 2 2 factorial was employed

The more melanin produced, the darker the skin appears

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It mainly includes scavenging free radicals (NOS) to alleviate the damage of melanocytes caused by oxidative stress, activating melanogenesis related pathways, increasing the expression of tyrosinase gene, reducing the expression of chemokines and inflammatory cytokines, preventing the migration of CD8 + T cells