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Autopsy studies of elderly patients with IPF have highlighted the severity and irreversibility of fibrotic remodeling in aged tissues, underscoring the importance of targeted therapeutic interventions [6]

The mechanisms of anemia in CKD include shortening red blood cell (RBC) survival, relative erythropoietin deficiency, folate or vitamin B12 deficiency due to anorexia, functional iron deficiency due to poor dietary iron absorption, higher iron requirements during erythropoietin supplementation, and overproduction of hepcidina regulator that inhibits iron transport by binding to ferroportinin a chronic inflammation state [119]

The beneficial cardiac effects of resveratrol have been attributed, at least in part, to the activation of SIRT1 (64)

doi: 10.2217/fon-2016-0547 58

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