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A major actin-sequestering protein in mammalian cells

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Upon recognition, macrophages undergo proinflammatory polarization and phagocytose of oxidized low density lipoprotein (oxLDL), ultimately leading to proatherogenic cytokine production and the formation of foam cells that contribute to plaque progression 2 (Fig

Given that FOXO4 is a transcription factor, this nuclear translocation suggests increased transcriptional activity