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Clinical Insight Social isolation is a potent, biologically mediated driver of negative affect and aggressionpartly via tachykinin 2 signalingwith preclinical evidence that NK3 receptor antagonism can normalize isolation-induced aggression, fear, and anxiety without sedation
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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 25% by weight of the cholesterol
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