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In drug development, high lipophilicity is frequently preferred, especially for intracellular medicines

In all three AMYRs, P37 Cagri and Y37 rAmy occupy the same pocket above W79 ECD of the CTR ECD where they form conserved interactions with surrounding residues (Fig

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Finally, acid oxidation of 8 followed by perchloric acid treatment in methylene chloride at room temperature yielded d,l- gliotoxin in a 65% yield