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They address multiple aging hallmarks simultaneously: metabolic dysfunction, chronic inflammation, cardiovascular risk, and potentially neurodegeneration

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

48 HuH.WangC.JinY.MengQ.LiuQ.LiuZ.et al (2019)

Lung exposure to noxious agents, including smoke, silica dust, nanosized silica, or carbon-derived nanomaterials can trigger mucosal toll-like receptors (TLRs) that activate Ca 2+ -mediated PADs, but also antigen-presenting cells (APCs), such as classical dendritic cells (DCs) and B cells

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Another function of Tau is revealed by its presence in the nucleus, where it has been reported to play roles in heterochromatin organization and chromatin stability by binding and interaction with heterochromatin, as well as modifying the liquidliquid phase separation (LLPS) characteristic of chromatin components (Abasi et al., 2024)