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The two main signaling cascades started by IGF1 LR3 receptor binding are the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the mitogen-started protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway

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Understanding the IGF-1 system in neurons, including the regulation of IGF-1 availability and signaling mechanisms, could be an important aspect for development of ALS therapeutic approaches 14