Myeloproliferative Disorders: These are a group of diseases (such as polycythaemia vera) that involve abnormal growth of blood cell precursors in the bone marrow
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However, some studies reported the inability of TAT-PTD to translocate monolayers of Caco-2 and MDCK epithelial cells (Violini et al., 2002), and in intestinal insulin absorption from the ileum in rats ( in vitro study of epithelial transport of insulin by D-form of arginine octamer (D-R8) indicated that cellular uptake is the critical step for efficient epithelial absorption and showed that D-R8 mediates intestinal epithelial transport of insulin by energy-independent unsaturable uptake ( Biotinylated transportan and its analog transportan 10 were reported to pass through epithelial Caco-2 monolayer cells mainly via transcellular transport and partly via paracellular pathway, while penetratin passes across cell monolayers in low yields, possibly due to partial degradation (Lindgren et al., 2004)
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