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Data reported so far demonstrated that oxidative agents, such as H2O2, and ROS-generating injuries such as UV-radiation, promote a transient APE/Ref-1 protein and mRNA induction which correlates with an increase of its endonuclease and redox activities

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Nitrate and nitrite in biology, nutrition and therapeutics

The peptide's antioxidant mechanism operates through activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, a master regulator of cellular antioxidant responses

Ignoring pulsatility may lead to inaccurate conclusions regarding receptor sensitivity, downstream pathway activation, and gene expression dynamics