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Also, some research suggests that Rosmarinus officinalis leaf extracts and some of their metabolites like indirubin (IND), prototype ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 6-formylindolo[3,2-b] carbazole (FICZ) and pityriazepin (PZ) inhibits the AhR activation (Aryl hydrocarbon receptor) in human keratinocytes

Curr Ther Res Clin Exp (2005) 66(1):1322.10.1016/j.curtheres.2005.02.001 15 ButlerCCVidal-AlaballJCannings-JohnRMcCaddonAHoodKPapaioannouAet alOral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials

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Likewise, the thiol compound NAC has demonstrated to exert a beneficial effect in the treatment of oxaliplatin induced-CINP, significantly reducing inflammatory response (TNF-, IL-1 and IL-6) in the neuroblastoma cell line SH-SY5Y

Therefore, riboflavin deficiency might be involved in the pathogenesis of migraine (27)