we have observed the same phenomenon with regard to desensitization of another metabotropic glutamate receptor, mGluR2 (S Lennon, PJ Roberts and E Kelly, unpublished observations)
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Furthermore, environmental pollutants, determining the formation of DNA adducts and abasic sites construction, can induce DNA modifications in gametes and embryos by introducing genetic mutations once unrepaired ( Nutritional Disorders A normal reproductive performance definitely requires a healthy nutrition since malnourished males and females are reported as major infertile populations in developing countries while, eating in excess, fast food consumption, hypercaloric dietary regimens and obesity, concur to infertility in well-developed and western societies
270,278,279 Under oxidative stress, disulfide bonds are formed, leading to the release of bound metals, particularly zinc, from MTs
