The hydrogel is biocompatible, strongly adheres to patellar, supraspinatus and Achilles tendons of live rats, boosted healing and reduced scar formation in a rat model of Achilles-tendon rupture, and sustainably released the corticosteroid triamcinolone acetonide in a rat model of patellar tendon injury, reducing inflammation, modulating chemokine secretion, recruiting tendon stem and progenitor cells, and promoting macrophage polarization to the M2 phenotype
The dual mechanism makes weight loss effective and helps improve chronic diseases and comorbid conditions ranging from high blood pressure, high cholesterol, morbid obesity, to Type 2 diabetes
Following recovery from surgery we behaviorally tested these animals utilizing the Morris water maze task of spatial learning which has become one of the gold standard behavioral testing protocols for the evaluation of AD animal models [37]
van Tienhoven-Wind LJ, Dullaart RP
Adachi S, Kawamoto T, Otsuka M, Todoroki T, Fukao K
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