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Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults

A 20 percent LDL reduction from a weight-loss-oriented triple agonist is therefore a genuinely new observation and helps explain why retatrutide is being developed across cardiovascular, metabolic, and weight-related indications rather than as a pure obesity asset

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10.1016/j.ejphar.2003.08.013 [DOI] [PubMed] [Google Scholar] Belosic Halle Z., Vlainic J., Drmic D., Strinic D., Luetic K., Sucic M., et al

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