Discovery of direct inhibitors of Keap1Nrf2 proteinprotein interaction as potential therapeutic and preventive agents
By employing a -adrenergic receptor blocker and a ghrelin receptor antagonist, they discovered that the oral intake of hydrogen water activates the -adrenergic receptor signaling pathway in the stomach, inducing ghrelin secretion, which in turn protects dopaminergic neurons in MPTP-induced PD model mice
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Long-term benefits include lowering risk factors associated with cardiovascular disease, diabetes, and neurodegenerative conditions, making it a comprehensive solution for healthy aging and overall wellness
Therefore, this study aims to investigate the interplay between epigenetic modifications, oxidative stress, and trace element imbalances in the pathogenesis of polycystic ovary syndrome using a dehydroepiandrosterone (DHEA)-induced rat model
doi: 10.14715/cmb/2019.65.1.5 45 La FontaineS.MercerJ
