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Cagrilintide Reconstitution Cagrilintide - dose per draw at common vial sizes Vial Size 5 mg BAC Water 2.0 mL Concentration 2.5 mg/mL 0.25 mg 0.10 mL (10 units) 0.5 mg 0.20 mL (20 units) 1.0 mg 0.40 mL (40 units) 2.4 mg 0.96 mL (96 units) Vial Size 10 mg BAC Water 2.0 mL Concentration 5.0 mg/mL 0.25 mg 0.05 mL (5 units) 0.5 mg 0.10 mL (10 units) 1.0 mg 0.20 mL (20 units) 2.4 mg 0.48 mL (48 units) Vial Size 10 mg BAC Water 1.0 mL Concentration 10.0 mg/mL 0.25 mg 0.025 mL (2.5 units) 0.5 mg 0.05 mL (5 units) 1.0 mg 0.10 mL (10 units) 2.4 mg 0.24 mL (24 units) Cagrilintide is sensitive - inject BAC water down the vial wall and swirl gently

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The animals were kept in a 12-hour light/dark cycle and maintained on standard rat laboratory chow and tap water ad libitum

Hours after injection: FOXO4-DRI enters circulation and, due to its D-amino acid structure, resists proteolytic degradation