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Some phagocytes have the capacity to secrete enzymes called myeleoperoxidases that can catalyze a reaction of H 2 O 2 and halides (chloride or bromide) to produce hypochlorous acid (HOCl) or hypobromous acid (HOBr) (Bakkenist et al., 1980)

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Lastly, epithalon plays a significant role in the endocrine system by increasing levels of endogenous hormones that naturally diminish with age, such as melatonin (which helps regulate the sleep cycle), and gonadotropic hormones (FSG, LG, prolactin), which play a role in reproductive functions [8]

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The underlying driver is chronic inflammationspecifically, dysregulated immune signaling involving TNF-, interleukins (IL-17, IL-23), and NF-B pathways

Ann Pharmacother