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However, it remains unclear whether the thiomethyl shunt involved in the formation of S-CH 3 -APAP-S and SO-CH 3 -APAP-S is preferentially occurring in the liver (before excretion of thiomethyl metabolites in the bile), or via the microbiota ( 26, 27 )

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Although G.HCl is not considered effective in contrast to GS 13 , when combined with chondroitin sulfate in the latter study 12 , it provided statistically significant pain relief compared with placebo in a subset of patients with moderate to severe knee pain

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