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Upon activation, NLRP3 engages the scaffold protein NIMA related kinase 7 (NEK7) and recruits the adaptor apoptosis-associated speck-like protein containing a CARD (PYD and CARD domain containing (PYCARD, also known as ASC)) to assemble the inflammasome complex

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In fact, fluid retention as a result of venous insufficiency is common, with the National Library of Medicine reporting that anywhere between 1-40% of females and 1-17% of males report suffering from venous insufficiency