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Glutamate-induced Ca 2+ influx and concurrent NO production act synergistically to impair mitochondrial function, further aggravating oxidative stress and cytotoxicity (Duchen 2004)

Monitoring for any signs of adverse reactions or injection site complications

Other Digestive enzyme supplements: If your dogs B12 deficiency is due to a digestive issue like EPI (see above section, What can cause B12 deficiency in dogs?), then adding a digestive enzyme supplement can help them break down food better and may improve the absorption of B12 and other nutrients

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Janurary 2018;24(1):33-38