Safety and Tolerability Preclinical studies suggest that 5-Amino-1MQ is well-tolerated with a favorable safety profile
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The D-Nle-Trp-Ile-NH(CH 2 ) 5 CONH 2 analog had intermediate inhibitory activity, and the D-Nle-Met-Ile-NH(CH 2 ) 5 CONH 2 analog showed no ability to effect on Met activation
Chen K, Lu Z, Wang X, Fu Y, Luo G, Liu N, et al
Taken together, these data suggest that inhibiting HGF does not alter the number of functional synapses in vehicle treated neurons but attenuates the effects of HGF and Dihexa on synaptogenesis by decreasing the number of postsynaptic spines
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