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Herrmann W, Obeid R
What is NNMT?+ NNMT (nicotinamide N-methyltransferase) is an enzyme expressed in fat tissue
As we age, NAD levels naturally declineleading to fatigue, brain fog, and slower recovery
Vegetarians and vegans, who do not consume animal products, are also considered at risk of B12 deficiency
After 4 weeks of oral administration of 5amino1mq tablets (510 mg/kg) to aged mice (1820 months old), muscle mass was significantly increased, grip strength was enhanced by approximately 40% compared with the control group, and muscle endurance and exercise capacity were also notably improved.Further studies revealed that 5amino1mq inhibits excessive NNMT activation in muscle tissue, restores NAD levels, activates the SIRT1 pathway, reduces muscle protein degradation, and promotes muscle protein synthesis, thereby maintaining muscle mass