4 This model is well-suited for reproducing inflammatory pain
GHK-Cu produced a concentration-dependent increase in the accumulation of connective tissue, measured as higher collagen and glycosaminoglycan content, higher DNA and protein, and increased collagen mRNAs in the harvested granulation tissue, while an inactive control peptide did not
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This may lead to autophosphorylation of a bidentate docking site in the carboxy-terminal cytoplasmic tail (tyrosine residues Tyr1349 and Tyr1356)
These findings suggest that our peptide exhibits potent functionality within cells as a senolytic drug, with selectivity for senescent cells
*Correspondence: Aalt Bast, Department of Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P