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In turn, an imbalanced microbiome can negatively affect the hosts circadian clock and metabolism ( Importantly, responses to melatonin supplementation and chrononutritional strategies exhibit substantial inter-individual variability among older adults

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Unlike many cofactors that directly participate in redox reactions, zinc's biological role largely involves structural stabilization and catalytic activity, making it indispensable in processes such as transcription, signal transduction, immune function, and apoptosis [5] (Tables 1 and 2)

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