Due to the co-occurrence of migraine and gastrointestinal (GI) disorders, this issue has received more attention
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However, too much oxidative stress can overwhelm our system
the mitochondria eventually undergo swelling of the cytoplasm and rupture of the outer membranes (174), with the release of endonucleases to degrade nuclear DNA (175, 176)
The concurrent proton flow, from the mitochondrial matrix to the intermembrane space, generates the intermembrane proton gradients, which are essential for oxidative phosphorylation and subsequent adenosine triphosphate (ATP) synthesis [5]
10.2174/1381612824666180712110447 [DOI] [PubMed] [Google Scholar] Sever, A