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Ensure airway patency and protection, provide mechanical ventilation where necessary, correct dysrhythmias, replace fluid and electrolytes (significant fluid losses generally occur and require aggressive rehydration), and monitor and treat the sequelae of organ dysfunction
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Research Ethics Committee approval was obtained in all six countries taking part in the ACTION study (NRES Committee North West - Liverpool East 14/NW/1189) and in the UK for the Namaste study (Wales Research Ethics Committee 5 Bangor 17/WA/0378)
This hypothesis is supported by elevations in brain HGF levels measured in several degenerative diseases including amyotrophic lateral sclerosis, multiple sclerosis, Parkinsons disease, spinal cord injury and AD [78-82]
Furthermore, the intestinal biopsies could only be obtained from a rather small group of patients due to the invasiveness of sampling and the complexity of the patient population
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