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10.1016/j.cell.2017.03.014 26 Prakash BabuN.PaolaM.Hamers AnoukA

A key aspect of FOXO4's function lies in its involvement in insulin and insulin-like growth factor (IGF) signaling pathways, which regulate metabolism, cell cycle progression, and apoptosis

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Although its primary mechanism was microbiota modulation, the resulting decrease in gut inflammation and oxidative stress was partly attributed to its reactive oxygen species-scavenging action and maintenance of mitochondrial function in epithelial cells

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A 173 , 25342538 (2017)