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Available from: Acknowledgements We would like to thank all hospitals (Virgen de las Nieves y San Cecilio, Granada), critically ill patients, ICU, and Clinical Analysis Service personnel, Dr

Extracellular GSH supplies cysteine The uptake of extracellular cystine through the cystineglutamate antiporter xCT is thought to be a major source of cysteine for tumours (Fig

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Binding of AngII to its AT1 receptor leads to the activation of MAP kinases, phosphorylation of tyrosine kinases and production of ROS, all of which induce VSMC proliferation