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A mice model for PCOS has been developed (ob/ob mice that are also leptin deficient), where mice are: - obese - hyperglycemic - hyperinsulinemic - insulin-resistant - exhibiting increased TNF-a and IL-6 levels, which promotes the state of chronic low-grade inflammation

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The peptide has gained significant scientific attention in longevity and regenerative medicine research due to its unique ability to induce apoptosis specifically in senescent cells while leaving healthy cells largely unaffected

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Predicted physicochemical properties supported its hydrophobic character and oral bioavailability, suggesting it is a metabolically stable and BBB-permeable molecule [2]

10.2165/00023210-200115040-00004 CNS Drugs 97 YaoJ