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Transl Psychiatry 5 , e632 (2015)

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Reconstituted solutions should not be repeatedly frozen and thawed, as this degrades peptide integrity

Overexpression of NLGN3 or 3A2 increases evoked inhibitory postsynaptic currents (IPSCs), while overexpression of NLGN3A1 or 3A1A2 leads to a reduction in IPSC amplitude

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Diminishing results despite consistent dosing is another signal