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Some of the largest US tobacco companies, including RJ Reynolds Tobacco Co and Lorillard Tobacco Co, had questioned the constitutionality of the labels, saying the warnings didn't simply convey facts to inform people's decision whether to smoke but instead forced the cigarette makers to display government anti-smoking advocacy more prominently than their own branding

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CAT is a validated health status questionnaire for use in COPD patients with a 2 unit change considered to be of minimal clinical important difference