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The honest summary is that long-term human safety data is missing and the angiogenesis mechanism is an unresolved theoretical concern

The combination of antioxidants and essential nutrients in Tomato Fruit helps protect cells from damage, supports cardiovascular health, and promotes healthy skin

It has been studied in research settings for its role in tissue repair processes involving muscles, tendons, ligaments, and skin.Research has also explored its interaction with protective mechanisms in organ systems and its involvement in maintaining digestive tract integrity

Brief interruptions (3-5 days) unlikely dramatically affecting 8-16 week protocols

Standard practice is brief draw-and-return handling rather than extended counter time

10.1371/journal.pone.0122714 PLoS One 247 WangS.ParthasarathyS.XiaoY.NishiyamaY.LongF.MatsudaI.et al (2015b)