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25 Moreover, Akt has the ability to stabilize the Cdc-like kinase 2 (Clk2) protein, which phosphorylates the serine-arginine domain of PGC-1 and represses the activity of PGC-1

1.2.5.2 Sulfur-containing antioxidants Compounds such as glutathione and lipoic acid protect neurons from oxidative damage and improve cognitive function

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Longevity Markers Gene-network studies report modulation of stress-response and proteostasis pathways

Impairing glutamine metabolism also induces sensitivity in gemcitabine-resistant pancreatic cancer cells 16,84,85