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Eligible patients were randomly assigned to either conventional fasting group (control group) or chewing gum with fasting group (gum group) at a ratio of 1:1, according to a randomization list generated by random permuted block design with a block size of two

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Although these pathways show that exposure to nicotine directly disrupts monoaminergic systems, disruptions of the endogenous cholinergic system, whether direct or indirect, remain a possibility

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